Targeting the Triple Negative Breast Tumour Microenvironment to Overcome Resistance to Immunotherapy (Novel approaches to overcome cancer resistance to conventional therapies) Kindle Edition

"Targeting the Triple Negative Breast Tumour Microenvironment to Overcome Resistance to Immunotherapy" explores the critical role of the tumor microenvironment (TME) in driving immunotherapy resistance in triple-negative breast cancer (TNBC). It addresses the urgent need to understand and target the TME to improve therapeutic outcomes in this aggressive cancer subtype. The content gives insight into the complex interactions within the TME, including immune cells, fibroblasts, and extracellular matrix components, that contribute to drug resistance. It integrates recent advancements in 3D organoid platforms, spatial omics, and combination therapy strategies, providing mechanistic insights and practical approaches to reprogramming the TME for enhanced treatment response. Academics and clinicians benefit from a comprehensive resource that bridges basic science and clinical application. This book equips researchers with cutting-edge knowledge and translational strategies, fostering innovation in cancer therapy and offering a roadmap for future drug development to overcome immunotherapy resistance in TNBC.• Provides detailed mechanistic insight into the complex interactions within the tumor microenvironment (TME) thats drive immunotherapy resistance• Incorporates recent advancements in 3D organoid platforms, spatial omics, and combination therapy strategies, showcasing the latest technologies and methodologies in cancer research• Bridges the gap between basic science and clinical application, offering translational strategies that academics can utilize to advance their research and contribute to future drug development Read more