REVGENETICS DiBerberine™ Proprietary Blend 500mg Supplement Enteric Coated | DHB Berberine Weight Support | AMPK Activation | 30 Capsules | DiBerberine 300x

"I spent months looking for this product. I couldn't find it. So I built it." - Anthony Loera, Founder, RevGenetics (Miami Florida, 33196) I wanted a dihydroberberine supplement with an enteric capsule, one that would actually protect the compound through stomach acid and deliver it intact to the small intestine, where absorption happens. What I found on the market was DHB in standard capsules. Standard capsules dissolve at pH 1.5–3.5. Stomach acid runs at pH 1.5–3.5. The DHB was converting back into regular berberine before it ever reached target tissue. That problem drove this formulation. THE THREE-LAYER DELIVERY SYSTEM IN DIBERBERINE 300X Layer 1: Enteric Coating: Acid-resistant capsule. Passes through the stomach sealed. Opens in the small intestine, where DHB remains active and optimal absorption occurs. As of March 2026, no other DHB supplement on Amazon uses this approach, verify competitor listings yourself. Layer 2: Dihydroberberine (DHB): Published pharmacokinetic data (PMC8746601) demonstrates 100mg DHB produced ~6.7x greater plasma berberine exposure (AUC) than 500mg standard berberine HCl. AMPK activation, the cellular energy pathway central to healthy metabolic function and fat oxidation, requires DHB to actually reach target tissue. Layer 3: Sophora japonica extract (as RGBooster1): Even after enteric delivery, P-glycoprotein efflux pumps actively expel DHB from cells before it activates AMPK. Sophora japonica extract (as RGBooster1) is our patent-pending (U.S. App. No. 63/837,080) flavonoid complex that modulates these pumps at 300x the potency of piperine at the P-gp efflux pathway, keeping DHB active at the cellular level longer. PLUS L-LEUCINE, BECAUSE METABOLIC HEALTH HAS TWO SIDES AMPK governs fat oxidation, metabolic efficiency, and cellular energy. mTOR governs muscle protein synthesis. L-Leucine is the primary BCAA involved in mTOR pathway signaling. No other DHB supplement on the market includes it (verified March 2026). DiBerberine 300x is the only DHB formula designed to support both pathways in a single capsule. WHAT TO EXPECT, AND WHY IT'S WORTH THE WAIT AMPK is an enzyme pathway, not a stimulant. It works cumulatively, which means DiBerberine 300x builds over time rather than producing an immediate sensation. Most users begin to notice meaningful results in the 6–8 week window with consistent daily use. Plan for a 30-day supply as your baseline commitment. That window is the same reason the 30-day bottle is our primary SKU, we built the offer around how the science actually works. You're not hoping something happens in your stomach and then your bloodstream. With DiBerberine 300x, the delivery system is engineered. The efflux pump is addressed. Both metabolic pathways are supported. Do your 8 weeks, then make your call. Made in the USA. cGMP certified. Third-party tested. Formulated by RevGenetics in Miami Florida, 33196. 30 enteric capsules per bottle. Take 1 capsule daily with a meal. Do not crush, chew, break, or open. *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.*

• You've Tried DHB Before and the Results Disappointed. Here's Why: Most DHB capsules dissolve in stomach acid, converting your expensive dihydroberberine back into regular berberine before absorption happens. DiBerberine 300x uses an enteric capsule that resists stomach acid and opens in the small intestine, where DHB stays active. As of March 2026, no other DHB supplement on Amazon uses an enteric capsule, verify competitor listings yourself. The capsule matters as much as what's inside it.
• Even If Your DHB Survives Your Stomach, Your Cells May Still Reject It: P-glycoprotein efflux pumps are cellular ejection mechanisms that actively expel DHB before it can activate AMPK, the metabolic pathway you're taking berberine for in the first place. Sophora japonica extract (as RGBooster1) is our patent-pending (U.S. App. No. 63/837,080) flavonoid complex that targets and modulates these pumps at 300x the potency of piperine at the P-gp pathway specifically. Different mechanism. Upstream fix. The DHB stays where it needs to be.
• One Capsule Daily vs. 3–6 Capsules, DHB Shows ~6.7x Greater Plasma Exposure Than Standard Berberine HCl: Standard berberine requires 3–6 capsules a day, and P-glycoprotein pumps still eject most of it before it reaches target tissues. Published pharmacokinetic data (PMC8746601) demonstrates 100mg DHB produced ~6.7x greater plasma berberine exposure (AUC) than 500mg standard berberine HCl. One 500mg DiBerberine Proprietary Blend enteric capsule per day. One capsule. More where it counts.
• Most DHB Formulas Activate One Pathway. This One Activates Two: AMPK (adenosine monophosphate-activated protein kinase) governs cellular energy, healthy metabolic function, and fat oxidation. mTOR governs muscle protein synthesis and retention. Most DHB products stop at AMPK. DiBerberine 300x includes L-Leucine, the primary BCAA involved in mTOR pathway signaling, making it the only DHB formula addressing both metabolic and muscle pathways simultaneously (verified March 2026). Results build over 6–8 weeks.
• Made in the USA | cGMP Certified | 3rd-Party Tested | Vegetable Cellulose (HPMC) Capsule | 30-Day Supply: Manufactured in a cGMP-certified US facility. Independently tested for potency, purity, and contaminants. Enteric capsule shell is vegetable cellulose (HPMC). Full 500mg DiBerberine Proprietary Blend per capsule, plus L-Leucine for the mTOR pathway. No fillers, no hidden ingredients. 30 enteric capsules per bottle. Formulated by RevGenetics, a founder-built brand from Miami Florida, since 2007, by someone who couldn't find this product and built it himself.